03 Jun 2019 --- The second research phase of the Human Microbiome Project (HMP), under the US National Institutes of Health (NIH) Common Fund, explores the complex set of chemical and molecular events that disrupt the microbiome and trigger immune responses during flare-ups of inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis. Findings from the study, to be published May 29, 2019 in Nature, reveal that different forms of IBD can have effects on the activity and composition of the microbiome, which in turn may cause adverse immune responses.