Four cups of coffee a day associated with lower risk of all-cause mortality

28 Aug 2017 --- Higher coffee consumption is associated with a lower risk of death, according to research presented at ESC Congress. The observational study in nearly 20,000 participants found that participants who consumed at least four cups of coffee per day had a 64 percent lower risk of all-cause mortality than those who never or almost never consumed coffee, providing further support for the suggestion that coffee can be part of a healthy diet in healthy people. 

“Coffee is one of the most widely consumed beverages around the world,” says Dr. Adela Navarro, a cardiologist at Hospital de Navarra, Pamplona, Spain. “Previous studies have suggested that drinking coffee might be inversely associated with all-cause mortality, but this has not been investigated in a Mediterranean country.”

An earlier, multinational study had shown in July that people who drink around three cups of coffee a day may live longer than non-coffee drinkers. In this study, scientists analyzed data on coffee consumption from more than half a million people across ten European countries. In a subset of 14,000 people, the researchers also analyzed metabolic biomarkers and found that coffee drinkers may have healthier livers overall and better glucose control than non-coffee drinkers.

The purpose of Navarro's study was to examine the association between coffee consumption and the risk of mortality in a middle-aged Mediterranean cohort. The study was conducted within the framework of the Seguimiento Universidad de Navarra (SUN) Project, a long-term prospective cohort study in more than 22,500 Spanish university graduates which started in 1999.

The study included 19,896 participants of the SUN Project, whose average age at enrollment was 37.7 years old. On entering the study, participants completed a previously validated semi-quantitative food frequency questionnaire to collect information on coffee consumption, lifestyle and sociodemographic characteristics, anthropometric measurements, and previous health conditions.

Patients were followed-up for an average of ten years. Information on mortality was obtained from study participants and their families, postal authorities, and the National Death Index. Cox regression models were used to estimate hazard ratios (HR) and 95 percent confidence intervals (CI) for incident mortality according to baseline total coffee consumption adjusted for potential confounders.

During the ten year period, 337 participants died. The researchers found that participants who consumed at least four cups of coffee per day had a 64 percent lower risk of all-cause mortality than those who never or almost never consumed coffee (adjusted HR, 0.36; 95 percent CI, 0.19–0.70). There was a 22 percent lower risk of all-cause mortality for each two additional cups of coffee per day (adjusted HR, 0.78; 95 percent CI, 0.66–0.92).

The researchers examined whether sex, age or adherence to the Mediterranean diet had any influence on the association between baseline coffee consumption and mortality. They observed a significant interaction between coffee consumption and age (p for interaction=0.0016). In those who were at least 45 years old, drinking two additional cups of coffee per day was associated with a 30 percent lower risk of mortality during follow-up (adjusted HR, 0.70; 95 percent CI, 0.58–0.85). The association was not significant among younger participants.

“In the SUN project, we found an inverse association between drinking coffee and the risk of all-cause mortality, particularly in people aged 45 years and above. This may be due to a stronger protective association among older participants,” Dr. Navarro says.

“Our findings suggest that drinking four cups of coffee each day can be part of a healthy diet in healthy people,” she concludes.