19 Mar 2018 --- The usage of the artificial sweetener sucralose, better known by the brand name Splenda, may intensify symptoms of Crohn’s disease in those who already have the condition, a study has found. The findings, published in Inflammatory Bowel Diseases, found that the sweetener worsened gut inflammation in mice who had Crohn’s-like disease. However Tate & Lyle, manufactures of Splenda, responded to the study saying, “We see no evidence in this study that contradicts the safety of sucralose ingredient.” The study found sucralose to have no adverse effects on healthy people.