01 Jul 2014 --- St. John's wort is the most frequently used complementary and alternative medicine (CAM) treatment in the U.S. for depression and similar psychiatric disorders. The many commonly prescribed medications that St. John's wort can interact with-sometimes with serious consequences such as serotonin syndrome or heart disease-are reviewed in The Journal of Alternative and Complementary Medicine, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.