A three-part research project at the Center for Research in Agricultural Genomics (CRAG), Spain, has made significant headway in understanding the molecular mechanisms of sorghum to advance its breeding. The world’s fifth most cultivated cereal is particularly important in arid and semi-arid regions, due to its natural resistance to drought and high temperatures. The CRAG researchers have identified the molecular mechanisms responsible for drought resistance in sorghum and developed tools that could be used in biotechnological applications.