20 May 2024 --- Japanese researchers linked the probiotic strain Clostridium butyricum with the prevalence of bacteremia — a condition where bacteria circulate in the bloodstream. The team from Osaka University cautions that while probiotics provide various health benefits, the study shows that even such agents can present with severe but rare adverse events. The researchers studied the genetic materials of bacteria in hospitalized patients with bacteremia who were admitted to Osaka University Hospital between September 2011 and February 2023. Among the 6,576 patients with positive blood cultures for bacteria, the team found five (0.08%) cases of C. butyricum bacteremia.