06 May 2024 --- Researchers suggest that psilocybin is a more effective treatment for symptoms of depression than controls. They reviewed randomized controlled trials that compared the compound of “magic” mushrooms with controls, such as placebo, niacin (vitamin B) or microdoses of psychedelics. The review found the most significant improvements for psilocybin treatment for patients with secondary depression — related to an underlying disease — instead of primary depression, self-reported scale rather than using a clinician-assessed scale, older age and previous use of psychedelics.