21 Feb 2024 --- Scientists reveal that consuming over 22% of dietary calories from protein can lead to an increased risk of atherosclerosis — the plaque or buildup of fats, cholesterol and other substances on artery walls — by activating immune cells involved in the process. Recent clinical studies suggest that the amino acid leucine plays a crucial role in driving the formation of arterial plaque, which causes the majority of heart attacks and strokes. This adverse effect of high protein on heart health is driven by the activation of a signaling pathway (mTORC1) that has been implicated in heart disease development. The researchers conclude that leucine is a key activator of this pathway.
