10 Jun 2020 --- There is not enough evidence to validate the use of probiotics for most digestive diseases, according to new guidelines from the American Gastroenterological Association (AGA). As a result of identifying just three clinical scenarios where probiotics may benefit patients, AGA only supports the use of certain probiotic formulations in specific settings. This could present a major blow to the burgeoning probiotic market, which has seen increasing attention in recent years.