14 Aug 2019 --- A high-fat diet can weaken the gut immune system and lead to insulin resistance and, ultimately, diabetes. This is according to new research published in Nature Communications, which showed how a high-fat diet influences one component of the gut immune system called B cells, specifically those that produce a protein called IgA. This class of antibodies regulates pathogenic bacteria and protects against a “leaky gut” and additional complications of obesity. These findings could be used to develop therapies that boost IgA in the gut, as well as creating new prevention strategies, the research team shared with NutritionInsight.
