06 Mar 2019 --- Although supplementation has been put forward as a solid method to improve mood and overall well being, a daily intake of nutritional supplements won’t help stave off the onset of depression, a study published in the Journal of the American Medical Association (JAMA) has shown. Instead, regular lifestyle coaching to help people improve their diets and eating behavior, as well as weight loss, may provide a more effective method for preventing depression, the researchers note. The study used supplements which contained folic acid, vitamin D, omega 3 fish oils, zinc and selenium.