Melatonin May Have Future Potential in Addressing Osteoporosis

27 May 2014 --- McGill researchers have shown that melatonin supplements may make bones stronger in old rats. This suggests a possible avenue for the prevention of osteoporosis. Bones are built up by certain cells known as osteoblasts during the daytime and broken down by others (osteoclasts) at night. As we age, we sleep less, and so the cells that break down the bones are more active.

By giving old rats melatonin supplements to regulate their circadian rhythms, the McGill researchers have been able to make their bones denser, less brittle and more flexible. Next step is to explore whether melatonin supplements prevent bone breakdown or can actually repair damage.

Faleh Tamimi, a professor in McGill's School of Dentistry, is the leader of a research team that has just discovered that melatonin supplements make bones stronger in elderly rats and therefore, potentially, in elderly humans too. "Old rats are tedious to work with because they get sick a lot and that means they also cost a lot more. But if you're interested in diseases like osteoporosis, they're an essential part of the process."

The process of bone breakdown and buildup is affected by our circadian rhythms. The cells which break down our bones (known as osteoclasts) are more active at night, while those responsible for bone formation (osteoblasts) are more active during daylight hours. "As we age, we sleep less well, which means that the osteoclasts are more active," says Tamimi. "This tends to speed up the process of bone breakdown."

It is already well established that melatonin plays a role in regulating our body clocks and can potentially help us sleep better. So the researchers suspected that a melatonin supplement would help regulate the circadian rhythms of the elderly rats, thus reducing the activity of the osteoclasts and slowing down the process of bone breakdown. And that is exactly what they found.

Researchers at the University of Madrid, where the rats were housed, gave twenty 22-month-old male rats (the equivalent of 60 year-old humans) melatonin supplements diluted in water for 10 weeks (the equivalent of six years in human years). The femurs taken from the elderly rats which had received the melatonin supplements were then compared with those of a control group (which had not received the supplements) using a series of tests to measure bone density and strength.

The researchers found that there was a significant increase in both bone volume and density among the rats that had received melatonin supplements. As a result, it took much more force to break the bones of rats that had taken the melatonin supplements, a finding that suggests to the researchers that melatonin may prove a useful tool in combatting osteoporosis.

For Tamimi and his colleagues the next big question is whether melatonin is preventing or actually reversing the process of bone breakdown. "Until there is more research as well as clinical trials to determine how exactly the melatonin is working, we can't recommend that people with osteoporosis go ahead and simply take melatonin supplements," says Tamimi. "I am applying for funding to pursue the research and we hope to have answers soon."

Melatonin dietary supplement as an anti-aging therapy for age-related bone loss Mrs. ISABEL F TRESGUERRES, Prof. Faleh Tamimi, Mr. Hazem Eimar, Jake Barralet, Dr. Santiago Prieto, Dr. Jesus Torres, Prof. Jose Luis Calvo-Guirado, and Jesús Angel Fernández-Tresguerres. Rejuvenation Research. -Not available-, ahead of print. doi:10.1089/rej.2013.1542.