23 Aug 2017 --- Vitamins B6 and B12 have been long touted by the vitamin industry for increasing energy and improving metabolism, and possibly even reducing cancer risk. However, new research suggests that long-term, high-dose supplementation is associated with a two- to four-fold increase in lung cancer risk in men relative to non-users. This is the first prospective, observational study to look at the effects of long-term high-dose B6/B12 supplement use and lung cancer risk.