Gnosis by Lesaffre touts the results of a recent study, which compares Hy-Folic — produced by Simex Pharmaceutical Indonesia — with its Quatrefolic folic acid. The study reveals that after a single oral dose in healthy volunteers. Hy-Folic is twice as bioavailable as folic acid and utilizes Quatrefolic, consisting of (6S)-5-methyltetrahydrofolic acid (5-MTHF) and glucosamine salt as its active form of folate.