27 Jul 2021 --- S-adenosyl-L-methionine (SAMe) may help with depression, pain, fatigue and the cognition of patients with mild Traumatic Brain Injury (mTBI), according to a new review focusing on the military. However, SAMe manufacturer Gnosis by Lesaffre – which was not directly involved with this specific review – highlights that the review suggests the compound’s usefulness can also extend to civilian populations.