In a landmark longevity study, scientists at the biopharmaceutical company CCM Biosciences have discovered enzyme activators that restore a “previously undruggable” mitochondrial regulator of cellular energy production to youthful activity levels. These enzyme-stimulating compounds show promise for cellular rejuvenation and treating age-related diseases, the company highlights. However, their development has been challenging due to reliance on allosteric modulation — a mechanism feasible in less than 10% of proteins.
