25 Feb 2019 --- Non-caloric sweeteners have a negligible effect on the gut microbiome and are not significantly linked to cancer and diabetes risk, as long as their consumption is in line with the ADI (Acceptable Daily Intake) recommended intake. This is according to a University of Granada (UGR) study, published in Advances in Nutrition, which reviewed previous evidence on the effects of sweeteners on gut microbiota through experimental research and clinical trials. The researchers note the need for more research on the effects of sweeteners on the composition of human gut microbiota, however.