A clinical trial on a dsm-firmenich synbiotic blend finds that daily three-month supplementation may help manage key clinical features of post-COVID-19 chronic fatigue syndrome (CFS). The combination of four strains from the company’s Humiome portfolio, fructooligosaccharides (FOS), and zinc attenuated post-exercise malaise and increased brain metabolites in adults suffering from CFS. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and long-lasting neurological condition characterized by symptoms such as severe fatigue, unrefreshing sleep, post-exercise malaise — where the body is unable to recover from exercise — and irregularities in brain metabolism.