18 Sep 2017 --- Decreased glucose metabolism in medial prefrontal areas of the brain is associated with nutritional status in patients with prodromal and early Alzheimer’s disease (AD), according to results from a Multimodal Neuroimaging for AD Diagnosis (MULNIAD) study. Nutritional problems, especially weight loss, are commonly seen in individuals with Alzheimer’s disease; however, the underlying mechanisms are not well understood.