High-fat meals are known to be stressors to the vascular endothelium, the interior lining of blood vessels. Any impairment made to the vascular endothelium may result in vascular dysfunctions.
13/03/09 Previous studies suggested that L-Carnitine supplementation may result in improved vascular function in humans with endothelial dysfunction. However, no studies directly evaluated the effects of L-Carnitine supplementation on vascular function in healthy humans after consuming a high-fat meal. Research conducted by the Department of Kinesiology at the University of Connecticut was published in the November 2008 issue of the American Journal of Cardiology. The study demonstrated that supplementation of Carnipure tartrate, a special form of L-Carnitine produced by Lonza, improves flow-mediated dilation (FMD) in the brachial artery after consuming a high-fat meal. Improved FMD corresponds to improved vascular function.
High-fat meals are known to be stressors to the vascular endothelium, the interior lining of blood vessels. Any impairment made to the vascular endothelium may result in vascular dysfunctions.
Flow-mediated dilation in the brachial artery of the study subjects was found to increase significantly after a high-fat meal was consumed with Carnipure tartrate and preceded by supplementation of Carnipure tartrate. This effect was not demonstrated in the placebo group. This led to the conclusion that supplementation with Carnipure tartrate may improve vascular function in healthy individuals.
L-Carnitine is produced by the body and plays a critical role in fat and energy metabolism. It carries long-chain fatty acids, one of the primary energy sources for our body, into the mitochondria where they are broken down for energy generation. A vast amount of research has shown that Carnipure tartrate supplementation may support cardiovascular health.
Lonza is the only manufacturer of the Carnipure brand of L-Carnitine products including Carnipure tartrate (U.S. Patent 5073376, Japan Patent JP 2546068 and other international patents). Carnipure tartrate consists of 68% pure L-Carnitine and 32% L-tartaric acid and is self affirmed as GRAS (Generally Recognized as Safe). Carnipure products are crystalline, white, water-soluble and heat stable which makes them ideal for use in various food and drink applications. In addition, Carnipure tartrate is non-hygroscopic, odorless, has a pleasant citrus taste and excellent flowability.
