10 Sep 2018 --- Foods high in unsaturated fats, such as olive oil, may protect against cardiovascular disease, and new research published in Nature Communications has uncovered why. Apolipoprotein A-IV, known as ApoA-IV, is a plasma protein. Levels of this protein increase after the digestion of foods, particularly foods high in unsaturated fats. Higher levels of ApoA-IV in the blood have been linked to lower rates of cardiovascular disease.