02 Nov 2017 --- Researchers studying the natural, plant-derived compound berberine have linked its anti-inflammatory activity and ability to regulate levels of stress-response proteins including sirtuin to berberine’s positive effects on memory loss and impaired learning. In addition to improving diabetic encephalopathy and slowing central nervous system degeneration, berberine was also associated with better lipid metabolism and decreased fasting glucose in aging diabetic mice.